Cell interactions with hierarchically structured nano-patterned adhesive surfaces

Cell interactions with hierarchically structured nano-patterned adhesive surfaces.

The activation of well-defined numbers of integrin molecules in predefined areas by adhesion of tissue cells to biofunctionalized micro-nanopatterned surfaces was used to determine the minimum number of activated integrins necessary to stimulate focal adhesion formation. This was realized by combining micellar and conventional e-beam lithography, which enabled deposition of 6 nm large gold nano...

Design of Hierarchically Sculptured Biological Surfaces with Anti-adhesive Properties

In many plant species sophisticated functions such as water repellence, reduction of particle adhesion and reduction of insect attachment are correlated to a hierarchically sculptured surface design. One prominent example is given by the hierarchically sculptured, self-cleaning surface of the lotus leave (Nelumbo nucifera). In plants hierarchy of surfaces is often realized by combining microstr...

Understanding the cell behavior on nano-/micro-patterned surfaces.

AIM This article reports on studies conducted in the same laboratory on interactions between patterned substrates with different pattern dimensions and chemistries, and various types of cells. MATERIALS & METHODS In order to compare the influence of various parameters, bone marrow stromal cells, retinal pigment epithelial cells, human corneal stromal cells (keratocytes), Saos-2 (human osteosa...

Anti-bioadhesion on hierarchically structured, superhydrophobic surfaces.

We prepared hierarchically structured, superhydrophobic surfaces, with single-, dual-, and triple-scale roughness, via a layer-by-layer (LbL) particle deposition approach. The dual-/triple-scale structured, superhydrophobic surfaces exhibited significantly reduced protein adsorption (up to a 90% decrease). Furthermore, platelet adhesion and activation was completely suppressed on the triple-sca...

Gecko Foot Mimetic Carbon Nanotube Patterned Adhesive Surfaces